Dendritic cells and immunoregulation in transplantation and immunopathology
Team 1

Our research team existing since 1994 has been interested in the cellular and molecular mechanisms of allograft tolerance and the functions of dendritic cell subsets. These projects identified new potential cellular and molecular targets for immunoregulation and led to the launching of the first clinical trial of tolerogenic DC administration in renal transplantation. The theme has been expanded over years to immune mediated inflammatory diseases (IMIDs) and transplant-related viral infections.



The team currently comprises seven permanent scientists and a total of around 30 people. Our research project, which includes fundamental and translational aspects, is organized around 3 major axes:

1. Functions of selected regulatory molecules in immune responses and IMIDs

        a.    TMEM176b/TORID. PI: MC Cuturi and C Louvet
        b.    CLEC-1. PI: E Chiffoleau
        c.    IL-22 binding protein (IL-22BP). PI: R Josien

2. Regulatory antigen presenting cells and cell therapies.

        a.    Tolerogenic dendritic cells. PI: MC Cuturi and A Moreau
        b.    Regulatory B cells. PI: E Chiffoleau

3. Dendritic cells and immune responses to transplant-related viruses

        a.    Interaction with and sensing of hCMV/BKPyV by DCs: PI: F Halary and C Bressollette
        b.    Immune responses to BKPyV/HHV6 in transplanted patients. PI: C Bressollette and BM Imbert

Translational projects, access to human samples and clinical developments are promoted by internal and external interactions between basic researchers and clinicians and the association of a Clinical Immunomonitoring Platform (CIMNA) to the team.



Credit. Designed by Jcomp / Freepik