Genetic and Cellular Engineering in Immunology and Regenerative Medicine
Main areas of research:
- Long-standing and present focus on CD8+ Tregs and mediators of tolerance by these cells, such as IL-34. Implementation of methods for cell therapy with CD8+ Tregs.
- Presently developing strategies to increase endogenous sources of Tregs through the use of anti-CD45RC MAbs depleting CD45RChigh Teff cells and sparing CD8+ and CD4+ CD45RClow Tregs.
Gene editing and gene transfer techniques:
- Long lasting and present focus in the generation of genetically modified rats using ZFNs, TALENs and CRISPRs.
- The use of viral gene transfer vectors for immune mediators.